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Sep 18

Camera calibration for the surround-view system: a benchmark and dataset

Surround-view system (SVS) is widely used in the Advanced Driver Assistance System (ADAS). SVS uses four fisheye lenses to monitor real-time scenes around the vehicle. However, accurate intrinsic and extrinsic parameter estimation is required for the proper functioning of the system. At present, the intrinsic calibration can be pipeline by utilizing checkerboard algorithm, while extrinsic calibration is still immature. Therefore, we proposed a specific calibration pipeline to estimate extrinsic parameters robustly. This scheme takes a driving sequence of four cameras as input. It firstly utilizes lane line to roughly estimate each camera pose. Considering the environmental condition differences in each camera, we separately select strategies from two methods to accurately estimate the extrinsic parameters. To achieve accurate estimates for both front and rear camera, we proposed a method that mutually iterating line detection and pose estimation. As for bilateral camera, we iteratively adjust the camera pose and position by minimizing texture and edge error between ground projections of adjacent cameras. After estimating the extrinsic parameters, the surround-view image can be synthesized by homography-based transformation. The proposed pipeline can robustly estimate the four SVS camera extrinsic parameters in real driving environments. In addition, to evaluate the proposed scheme, we build a surround-view fisheye dataset, which contains 40 videos with 32,000 frames, acquired from different real traffic scenarios. All the frames in each video are manually labeled with lane annotation, with its GT extrinsic parameters. Moreover, this surround-view dataset could be used by other researchers to evaluate their performance. The dataset will be available soon.

  • 5 authors
·
Dec 27, 2023

MetaOcc: Surround-View 4D Radar and Camera Fusion Framework for 3D Occupancy Prediction with Dual Training Strategies

3D occupancy prediction is crucial for autonomous driving perception. Fusion of 4D radar and camera provides a potential solution of robust occupancy prediction on serve weather with least cost. How to achieve effective multi-modal feature fusion and reduce annotation costs remains significant challenges. In this work, we propose MetaOcc, a novel multi-modal occupancy prediction framework that fuses surround-view cameras and 4D radar for comprehensive environmental perception. We first design a height self-attention module for effective 3D feature extraction from sparse radar points. Then, a local-global fusion mechanism is proposed to adaptively capture modality contributions while handling spatio-temporal misalignments. Temporal alignment and fusion module is employed to further aggregate historical feature. Furthermore, we develop a semi-supervised training procedure leveraging open-set segmentor and geometric constraints for pseudo-label generation, enabling robust perception with limited annotations. Extensive experiments on OmniHD-Scenes dataset demonstrate that MetaOcc achieves state-of-the-art performance, surpassing previous methods by significant margins. Notably, as the first semi-supervised 4D radar and camera fusion-based occupancy prediction approach, MetaOcc maintains 92.5% of the fully-supervised performance while using only 50% of ground truth annotations, establishing a new benchmark for multi-modal 3D occupancy prediction. Code and data are available at https://github.com/LucasYang567/MetaOcc.

  • 10 authors
·
Jan 25, 2025

ParkGaussian: Surround-view 3D Gaussian Splatting for Autonomous Parking

Parking is a critical task for autonomous driving systems (ADS), with unique challenges in crowded parking slots and GPS-denied environments. However, existing works focus on 2D parking slot perception, mapping, and localization, 3D reconstruction remains underexplored, which is crucial for capturing complex spatial geometry in parking scenarios. Naively improving the visual quality of reconstructed parking scenes does not directly benefit autonomous parking, as the key entry point for parking is the slots perception module. To address these limitations, we curate the first benchmark named ParkRecon3D, specifically designed for parking scene reconstruction. It includes sensor data from four surround-view fisheye cameras with calibrated extrinsics and dense parking slot annotations. We then propose ParkGaussian, the first framework that integrates 3D Gaussian Splatting (3DGS) for parking scene reconstruction. To further improve the alignment between reconstruction and downstream parking slot detection, we introduce a slot-aware reconstruction strategy that leverages existing parking perception methods to enhance the synthesis quality of slot regions. Experiments on ParkRecon3D demonstrate that ParkGaussian achieves state-of-the-art reconstruction quality and better preserves perception consistency for downstream tasks. The code and dataset will be released at: https://github.com/wm-research/ParkGaussian

  • 13 authors
·
Jan 4

CylinderDepth: Cylindrical Spatial Attention for Multi-View Consistent Self-Supervised Surround Depth Estimation

Self-supervised surround-view depth estimation enables dense, low-cost 3D perception with a 360° field of view from multiple minimally overlapping images. Yet, most existing methods suffer from depth estimates that are inconsistent across overlapping images. To address this limitation, we propose a novel geometry-guided method for calibrated, time-synchronized multi-camera rigs that predicts dense metric depth. Our approach targets two main sources of inconsistency: the limited receptive field in border regions of single-image depth estimation, and the difficulty of correspondence matching. We mitigate these two issues by extending the receptive field across views and restricting cross-view attention to a small neighborhood. To this end, we establish the neighborhood relationships between images by mapping the image-specific feature positions onto a shared cylinder. Based on the cylindrical positions, we apply an explicit spatial attention mechanism, with non-learned weighting, that aggregates features across images according to their distances on the cylinder. The modulated features are then decoded into a depth map for each view. Evaluated on the DDAD and nuScenes datasets, our method improves both cross-view depth consistency and overall depth accuracy compared with state-of-the-art approaches. Code is available at https://abualhanud.github.io/CylinderDepthPage.

SV-WAM: An Efficient Surround-View World-Action Model for End-to-End Autonomous Driving

World models (WMs) have demonstrated strong potential for end-to-end autonomous driving by learning predictive representations of future scene dynamics. However, generating future videos during inference introduces substantial computational overhead, leading many recent driving WMs to adopt a single front camera as input for efficient deployment. This design restricts spatial coverage in safety-critical maneuvers such as lane changes, merges, and turns. To address this limitation, we propose SV-WAM, a surround-view world-action model (WAM) that preserves full six-camera observations while maintaining efficient inference. SV-WAM leverages future-video prediction as dense training supervision for action learning within a shared generative model, rather than as an inference-time output. At the core of this design is an action-centered causal mask that prevents action tokens from attending to future-video tokens during joint action-video denoising. Consequently, the video branch can be discarded at deployment, enabling efficient action-only planning. Furthermore, we introduce a differentiable drivable-area compliance regularizer that penalizes vehicle-footprint corners approaching or crossing drivable boundaries, improving planning safety and boundary awareness. Extensive experiments on the closed-loop NAVSIMv2 benchmark and the open-loop nuScenes benchmark demonstrate that SV-WAM achieves state-of-the-art planning performance with low inference latency and competitive zero-shot transfer capability.

  • 15 authors
·
Sep 2

Fisheye Camera and Ultrasonic Sensor Fusion For Near-Field Obstacle Perception in Bird's-Eye-View

Accurate obstacle identification represents a fundamental challenge within the scope of near-field perception for autonomous driving. Conventionally, fisheye cameras are frequently employed for comprehensive surround-view perception, including rear-view obstacle localization. However, the performance of such cameras can significantly deteriorate in low-light conditions, during nighttime, or when subjected to intense sun glare. Conversely, cost-effective sensors like ultrasonic sensors remain largely unaffected under these conditions. Therefore, we present, to our knowledge, the first end-to-end multimodal fusion model tailored for efficient obstacle perception in a bird's-eye-view (BEV) perspective, utilizing fisheye cameras and ultrasonic sensors. Initially, ResNeXt-50 is employed as a set of unimodal encoders to extract features specific to each modality. Subsequently, the feature space associated with the visible spectrum undergoes transformation into BEV. The fusion of these two modalities is facilitated via concatenation. At the same time, the ultrasonic spectrum-based unimodal feature maps pass through content-aware dilated convolution, applied to mitigate the sensor misalignment between two sensors in the fused feature space. Finally, the fused features are utilized by a two-stage semantic occupancy decoder to generate grid-wise predictions for precise obstacle perception. We conduct a systematic investigation to determine the optimal strategy for multimodal fusion of both sensors. We provide insights into our dataset creation procedures, annotation guidelines, and perform a thorough data analysis to ensure adequate coverage of all scenarios. When applied to our dataset, the experimental results underscore the robustness and effectiveness of our proposed multimodal fusion approach.

  • 7 authors
·
Feb 1, 2024

Deform360: A Massive Multi-view Visuotactile Dataset for Deformable World Models

Predicting object dynamics (i.e., world modeling) is a fundamental challenge for robotic manipulation, and modeling deformable objects presents a particularly difficult case due to their high-dimensional state spaces and complex material properties. While current world models approach this through two distinct paradigms: learning the dynamics over the 2D pixel space or more explicit 3D geometric space. A systematic understanding of their relative strengths and limitations remains elusive due to the lack of diverse, large-scale real-world data. To address this, we present Deform360, a large-scale visuotactile dataset featuring 198 daily-life objects, 1,980 interaction sequences, and over 215 hours of observations from 41 surround-view cameras and bimanual tactile grippers to capture both global motion and contact-induced local deformations. Leveraging a novel markerless visuotactile 3D tracking pipeline to extract dense geometry and motion, we systematically evaluate current state-of-the-art world models, comparing 2D video models against 3D particle models. Finally, we provide a preliminary demonstration indicating the real-world applicability of our dataset by performing robot planning tasks on deformable objects. Our analysis reveals key insights into the trade-offs between structural priors and scalability, providing a solid benchmark for future research in generalizable deformable object-centric world modeling. Project website: https://deform360.lhy.xyz

OmniHD-Scenes: A Next-Generation Multimodal Dataset for Autonomous Driving

The rapid advancement of deep learning has intensified the need for comprehensive data for use by autonomous driving algorithms. High-quality datasets are crucial for the development of effective data-driven autonomous driving solutions. Next-generation autonomous driving datasets must be multimodal, incorporating data from advanced sensors that feature extensive data coverage, detailed annotations, and diverse scene representation. To address this need, we present OmniHD-Scenes, a large-scale multimodal dataset that provides comprehensive omnidirectional high-definition data. The OmniHD-Scenes dataset combines data from 128-beam LiDAR, six cameras, and six 4D imaging radar systems to achieve full environmental perception. The dataset comprises 1501 clips, each approximately 30-s long, totaling more than 450K synchronized frames and more than 5.85 million synchronized sensor data points. We also propose a novel 4D annotation pipeline. To date, we have annotated 200 clips with more than 514K precise 3D bounding boxes. These clips also include semantic segmentation annotations for static scene elements. Additionally, we introduce a novel automated pipeline for generation of the dense occupancy ground truth, which effectively leverages information from non-key frames. Alongside the proposed dataset, we establish comprehensive evaluation metrics, baseline models, and benchmarks for 3D detection and semantic occupancy prediction. These benchmarks utilize surround-view cameras and 4D imaging radar to explore cost-effective sensor solutions for autonomous driving applications. Extensive experiments demonstrate the effectiveness of our low-cost sensor configuration and its robustness under adverse conditions. Data will be released at https://www.2077ai.com/OmniHD-Scenes.

  • 13 authors
·
Dec 14, 2024

Multiagent Multitraversal Multimodal Self-Driving: Open MARS Dataset

Large-scale datasets have fueled recent advancements in AI-based autonomous vehicle research. However, these datasets are usually collected from a single vehicle's one-time pass of a certain location, lacking multiagent interactions or repeated traversals of the same place. Such information could lead to transformative enhancements in autonomous vehicles' perception, prediction, and planning capabilities. To bridge this gap, in collaboration with the self-driving company May Mobility, we present the MARS dataset which unifies scenarios that enable MultiAgent, multitraveRSal, and multimodal autonomous vehicle research. More specifically, MARS is collected with a fleet of autonomous vehicles driving within a certain geographical area. Each vehicle has its own route and different vehicles may appear at nearby locations. Each vehicle is equipped with a LiDAR and surround-view RGB cameras. We curate two subsets in MARS: one facilitates collaborative driving with multiple vehicles simultaneously present at the same location, and the other enables memory retrospection through asynchronous traversals of the same location by multiple vehicles. We conduct experiments in place recognition and neural reconstruction. More importantly, MARS introduces new research opportunities and challenges such as multitraversal 3D reconstruction, multiagent perception, and unsupervised object discovery. Our data and codes can be found at https://ai4ce.github.io/MARS/.

  • 8 authors
·
Jun 13, 2024

VGOcc: Learning Visual-Geometric Gaussians for Vision-Centric 3D Driving Occupancy Prediction

Vision-only occupancy prediction requires recovering a semantic 3D occupancy field from calibrated surround-view images, where each view provides observations with ambiguous depth along camera rays. Existing methods have progressed from dense structured representations to sparse Gaussian primitives, improving the efficiency of 3D scene representation. However, Gaussian learning still relies primarily on image domain features, which provide limited explicit geometric information for volumetric reasoning. Our key observation is that effective Gaussian occupancy modeling requires not only sparse primitives, but also richer geometric and semantic learning cues. In this paper, we propose VGOcc, which learns visual and geometric cues from foundation models for Gaussian modeling. VGOcc incorporates these cues into primitive initialization and refinement, yielding a representation termed Visual-Geometric Gaussians tailored to semantic occupancy prediction. Specifically, we propose Visual-Geometric Gaussian Birth to form spatially balanced Gaussian centers from ray depth hypotheses, while visual semantic features initialize primitive attributes. Next, we design Pose-Aware Feature Learning to combine foundation tokens with camera embeddings and calibrated ray information. Features from neighboring views are then aggregated at projected 3D locations for each Gaussian refinement stage. Finally, Gaussian decoder refines birth Gaussians with pose-aware features and renders them into semantic occupancy. Experiments on nuScenes demonstrate that VGOcc achieves state-of-the-art performance in vision-only 3D occupancy prediction. Codes will be available at https://github.com/JHLin42in/VGOcc.

Visual Implicit Geometry Transformer for Autonomous Driving

We introduce the Visual Implicit Geometry Transformer (ViGT), an autonomous driving geometric model that estimates continuous 3D occupancy fields from surround-view camera rigs. ViGT represents a step towards foundational geometric models for autonomous driving, prioritizing scalability, architectural simplicity, and generalization across diverse sensor configurations. Our approach achieves this through a calibration-free architecture, enabling a single model to adapt to different sensor setups. Unlike general-purpose geometric foundational models that focus on pixel-aligned predictions, ViGT estimates a continuous 3D occupancy field in a birds-eye-view (BEV) addressing domain-specific requirements. ViGT naturally infers geometry from multiple camera views into a single metric coordinate frame, providing a common representation for multiple geometric tasks. Unlike most existing occupancy models, we adopt a self-supervised training procedure that leverages synchronized image-LiDAR pairs, eliminating the need for costly manual annotations. We validate the scalability and generalizability of our approach by training our model on a mixture of five large-scale autonomous driving datasets (NuScenes, Waymo, NuPlan, ONCE, and Argoverse) and achieving state-of-the-art performance on the pointmap estimation task, with the best average rank across all evaluated baselines. We further evaluate ViGT on the Occ3D-nuScenes benchmark, where ViGT achieves comparable performance with supervised methods. The source code is publicly available at https://github.com/whesense/ViGT{https://github.com/whesense/ViGT}.

  • 8 authors
·
Feb 5

SurroundNEXO: Ego-Centric Metric Bridging for Spatially Consistent Geometry in Autonomous Driving

Modern autonomous driving depends on accurate metric 3D understanding for perception, reconstruction, and planning, which in turn requires reliable multi-camera depth prediction. However, the outward-facing nature of vehicle-mounted surround-view camera rigs inherently limits visual overlap across views, challenging the correspondence-based assumptions that underpin conventional multi-view geometry. To bridge this gap, we present SurroundNEXO, named after the Spanish word nexo for a geometric link, a low-overlap multi-camera metric depth framework that grounds cross-view reasoning in ego-centric geometry rather than dense visual correspondences. Instead of directly enforcing early global fusion, SurroundNEXO first assigns image tokens globally comparable ego-frame viewing directions through Ego-Ray Positional Encoding, then uses sparse LiDAR measurements as metric anchors to propagate absolute scale cues, and finally expands feature interaction progressively from view-local modeling to decomposed spatio-temporal reasoning and global integration. This design enables metric-scale depth prediction with improved spatial consistency across weakly overlapping cameras. Across low-overlap autonomous driving benchmarks, including NuScenes, Waymo and DDAD, SurroundNEXO reduces single-view error by 33.2%, improves cross-view consistency by 10.5%, and enhances metric reconstruction quality by 25.6% compared with SOTA methods. It further remains robust under extremely sparse depth prompts and exhibits strong zero-shot generalization to unseen camera layouts.

  • 11 authors
·
Jun 14

VisionTrap: Vision-Augmented Trajectory Prediction Guided by Textual Descriptions

Predicting future trajectories for other road agents is an essential task for autonomous vehicles. Established trajectory prediction methods primarily use agent tracks generated by a detection and tracking system and HD map as inputs. In this work, we propose a novel method that also incorporates visual input from surround-view cameras, allowing the model to utilize visual cues such as human gazes and gestures, road conditions, vehicle turn signals, etc, which are typically hidden from the model in prior methods. Furthermore, we use textual descriptions generated by a Vision-Language Model (VLM) and refined by a Large Language Model (LLM) as supervision during training to guide the model on what to learn from the input data. Despite using these extra inputs, our method achieves a latency of 53 ms, making it feasible for real-time processing, which is significantly faster than that of previous single-agent prediction methods with similar performance. Our experiments show that both the visual inputs and the textual descriptions contribute to improvements in trajectory prediction performance, and our qualitative analysis highlights how the model is able to exploit these additional inputs. Lastly, in this work we create and release the nuScenes-Text dataset, which augments the established nuScenes dataset with rich textual annotations for every scene, demonstrating the positive impact of utilizing VLM on trajectory prediction. Our project page is at https://moonseokha.github.io/VisionTrap/

  • 9 authors
·
Jul 17, 2024

AffordBot: 3D Fine-grained Embodied Reasoning via Multimodal Large Language Models

Effective human-agent collaboration in physical environments requires understanding not only what to act upon, but also where the actionable elements are and how to interact with them. Existing approaches often operate at the object level or disjointedly handle fine-grained affordance reasoning, lacking coherent, instruction-driven grounding and reasoning. In this work, we introduce a new task: Fine-grained 3D Embodied Reasoning, which requires an agent to predict, for each referenced affordance element in a 3D scene, a structured triplet comprising its spatial location, motion type, and motion axis, based on a task instruction. To solve this task, we propose AffordBot, a novel framework that integrates Multimodal Large Language Models (MLLMs) with a tailored chain-of-thought (CoT) reasoning paradigm. To bridge the gap between 3D input and 2D-compatible MLLMs, we render surround-view images of the scene and project 3D element candidates into these views, forming a rich visual representation aligned with the scene geometry. Our CoT pipeline begins with an active perception stage, prompting the MLLM to select the most informative viewpoint based on the instruction, before proceeding with step-by-step reasoning to localize affordance elements and infer plausible interaction motions. Evaluated on the SceneFun3D dataset, AffordBot achieves state-of-the-art performance, demonstrating strong generalization and physically grounded reasoning with only 3D point cloud input and MLLMs.

  • 6 authors
·
Nov 13, 2025 2

OccAny: Generalized Unconstrained Urban 3D Occupancy

Relying on in-domain annotations and precise sensor-rig priors, existing 3D occupancy prediction methods are limited in both scalability and out-of-domain generalization. While recent visual geometry foundation models exhibit strong generalization capabilities, they were mainly designed for general purposes and lack one or more key ingredients required for urban occupancy prediction, namely metric prediction, geometry completion in cluttered scenes and adaptation to urban scenarios. We address this gap and present OccAny, the first unconstrained urban 3D occupancy model capable of operating on out-of-domain uncalibrated scenes to predict and complete metric occupancy coupled with segmentation features. OccAny is versatile and can predict occupancy from sequential, monocular, or surround-view images. Our contributions are three-fold: (i) we propose the first generalized 3D occupancy framework with (ii) Segmentation Forcing that improves occupancy quality while enabling mask-level prediction, and (iii) a Novel View Rendering pipeline that infers novel-view geometry to enable test-time view augmentation for geometry completion. Extensive experiments demonstrate that OccAny outperforms all visual geometry baselines on 3D occupancy prediction task, while remaining competitive with in-domain self-supervised methods across three input settings on two established urban occupancy prediction datasets. Our code is available at https://github.com/valeoai/OccAny .

  • 2 authors
·
Mar 24

4DLidarOpen: An Open 4D FMCW Lidar Dataset for Motion-Aware Autonomous Driving

We present 4DLidarOpen, a large-scale open multi-modal dataset for autonomous driving, centered on 4D frequency-modulated continuous-wave (FMCW) Lidar sensing. Unlike conventional time-of-flight Lidar datasets that mainly provide geometric measurements, 4DLidarOpen includes point-wise radial velocity measurements from a forward-facing 4D FMCW Lidar, together with multiple Lidars of different types, including rotating, solid-state, and blind-spot variants, surround-view cameras, and 6-DOF ego-vehicle poses. The dataset was collected in complex urban environments in Beijing and covers dense pedestrian interactions, congested traffic, high-speed driving, and unprotected maneuvers. 4DLidarOpen provides synchronized multi-sensor data and 3D bounding-box annotations with persistent track IDs across five object categories. A hybrid annotation strategy is adopted, where large-scale auto-labeled data support scalable training and human experts refine annotations for the human-annotated training and validation sets. Based on this dataset, we establish benchmarks for 3D object detection, birds-eye view (BEV) segmentation and flow prediction, and motion forecasting with planning. Extensive experiments show that direct velocity measurements from 4D FMCW Lidar provide complementary motion cues for dynamic-scene understanding. Compared with geometric-only sensing, the velocity-aware representation improves motion-related perception and downstream forecasting and planning, especially in scenarios involving vulnerable road users and fast-moving objects. These results indicate that 4D FMCW Lidar is a promising sensing modality for motion-aware autonomous driving. The dataset and evaluation toolkit are publicly released to support research on 4D scene understanding, multi-Lidar fusion, and velocity-aware perception and planning.

  • 10 authors
·
May 17

Estimation of Appearance and Occupancy Information in Birds Eye View from Surround Monocular Images

Autonomous driving requires efficient reasoning about the location and appearance of the different agents in the scene, which aids in downstream tasks such as object detection, object tracking, and path planning. The past few years have witnessed a surge in approaches that combine the different taskbased modules of the classic self-driving stack into an End-toEnd(E2E) trainable learning system. These approaches replace perception, prediction, and sensor fusion modules with a single contiguous module with shared latent space embedding, from which one extracts a human-interpretable representation of the scene. One of the most popular representations is the Birds-eye View (BEV), which expresses the location of different traffic participants in the ego vehicle frame from a top-down view. However, a BEV does not capture the chromatic appearance information of the participants. To overcome this limitation, we propose a novel representation that captures various traffic participants appearance and occupancy information from an array of monocular cameras covering 360 deg field of view (FOV). We use a learned image embedding of all camera images to generate a BEV of the scene at any instant that captures both appearance and occupancy of the scene, which can aid in downstream tasks such as object tracking and executing language-based commands. We test the efficacy of our approach on synthetic dataset generated from CARLA. The code, data set, and results can be found at https://rebrand.ly/APP OCC-results.

  • 5 authors
·
Nov 8, 2022

PowerBEV: A Powerful Yet Lightweight Framework for Instance Prediction in Bird's-Eye View

Accurately perceiving instances and predicting their future motion are key tasks for autonomous vehicles, enabling them to navigate safely in complex urban traffic. While bird's-eye view (BEV) representations are commonplace in perception for autonomous driving, their potential in a motion prediction setting is less explored. Existing approaches for BEV instance prediction from surround cameras rely on a multi-task auto-regressive setup coupled with complex post-processing to predict future instances in a spatio-temporally consistent manner. In this paper, we depart from this paradigm and propose an efficient novel end-to-end framework named POWERBEV, which differs in several design choices aimed at reducing the inherent redundancy in previous methods. First, rather than predicting the future in an auto-regressive fashion, POWERBEV uses a parallel, multi-scale module built from lightweight 2D convolutional networks. Second, we show that segmentation and centripetal backward flow are sufficient for prediction, simplifying previous multi-task objectives by eliminating redundant output modalities. Building on this output representation, we propose a simple, flow warping-based post-processing approach which produces more stable instance associations across time. Through this lightweight yet powerful design, POWERBEV outperforms state-of-the-art baselines on the NuScenes Dataset and poses an alternative paradigm for BEV instance prediction. We made our code publicly available at: https://github.com/EdwardLeeLPZ/PowerBEV.

  • 6 authors
·
Jun 19, 2023

Leveraging Biomolecule and Natural Language through Multi-Modal Learning: A Survey

The integration of biomolecular modeling with natural language (BL) has emerged as a promising interdisciplinary area at the intersection of artificial intelligence, chemistry and biology. This approach leverages the rich, multifaceted descriptions of biomolecules contained within textual data sources to enhance our fundamental understanding and enable downstream computational tasks such as biomolecule property prediction. The fusion of the nuanced narratives expressed through natural language with the structural and functional specifics of biomolecules described via various molecular modeling techniques opens new avenues for comprehensively representing and analyzing biomolecules. By incorporating the contextual language data that surrounds biomolecules into their modeling, BL aims to capture a holistic view encompassing both the symbolic qualities conveyed through language as well as quantitative structural characteristics. In this review, we provide an extensive analysis of recent advancements achieved through cross modeling of biomolecules and natural language. (1) We begin by outlining the technical representations of biomolecules employed, including sequences, 2D graphs, and 3D structures. (2) We then examine in depth the rationale and key objectives underlying effective multi-modal integration of language and molecular data sources. (3) We subsequently survey the practical applications enabled to date in this developing research area. (4) We also compile and summarize the available resources and datasets to facilitate future work. (5) Looking ahead, we identify several promising research directions worthy of further exploration and investment to continue advancing the field. The related resources and contents are updating in https://github.com/QizhiPei/Awesome-Biomolecule-Language-Cross-Modeling.

  • 8 authors
·
Mar 3, 2024