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Mycotoxins are fungal metabolites known to be harmful to human and animal health. To date, there are many reports of disorders caused by mycotoxins in the digestive, urinary, immune and reproduction systems, and the importance of oxidative stress through lipid peroxidation has been stressed as a trigger of mycotoxin-in...
sub sup #text sup #text Pigs have an epitheliochorial and diffuse type of placenta (). Histologically, the surface of the allantochorion becomes complexly folded, producing ridges that fit into corresponding grooves or crypts in the endometrium (). In the interhemal area, the maternal vessels and fetal vessels are situ...
The standard amino acids are of the L-form, but their enantiomers, D-amino acids, are found in some proteins, such as peptidoglycan cell walls of bacteria. It has been reported that D-amino acids accumulated in different tissues, which might represent different physiological conditions. For example, accumulation of D-a...
Busulfan, a bifunctional alkylating agent, has been used for the treatment of chronic myeloid leukemia and for myeloablative-conditioning regimens before stem cell transplantation. In children, there are several reports of diverse effects of busulfan treatment such as pulmonary fibrosis and acute clinical neurotoxicity...
AZD3783 is a potent and selective antagonist of the human 5-hydroxytryptamine 1B (serotonin, or 5-HT) receptor, with a Ki of 12.5 nM. that is involved in physiological functions including thermoregulation, modulation of neurotransmitter release, as well as anxiety and mood regulation. release of serotonin, thus 5-HT an...
Prostate cancer is the most common cancer and the second leading cause of death from cancer among men in the US. It has been estimated there will be approximately 238,590 new cases of prostate cancer and 29,720 deaths from prostate cancer in the US in 2013. In Japan, the prevalence and mortality of prostate cancer has ...
Atrial dilatation and fibrillation are well-known risk factors for the development of thrombosis within the atrium. Thrombosis develops easily when blood pooling occurs in the left atrium, often leading to cardio-embolic stroke (CES). Since atrial thrombosis is strongly associated with CES, clarifying the mechanism res...
Trichothecene mycotoxins produced by fungi are frequent contaminants in agricultural commodities such as rice, wheat, rye, barley, oats, corn, and other cereals produced in various countries around the world. Contamination with these mycotoxins, including mycotoxins, remains a major concern for human and animal healt...
In general, hypoxia within tumor tissues plays a significant negative role in the treatment of malignant neoplasms, because the angiogenesis, evasion of apoptosis and increased glycolytic rate are all adaptations made by tumors in the hypoxic microenvironment. To improve therapeutic efficacy, recent efforts have been c...
Ricin, a powerful cytotoxic protein derived from the seeds of the castor oil plant, consists of two polypeptide chains named ricin toxin A chain (RTA) and ricin toxin B chain (RTB) linked via a disulfide bridge. RTB mediates the binding to glycolipids or glycoproteins on the cell surface via its lectin receptors, follo...
G-quadruplexes (GQs) are noncanonical secondary structures formed from G-rich sequences of nucleic acids, and play important roles in the regulation of gene transcription and translation. Formation of GQs in a telomere region causes inhibition of telomerase activity with subsequent obsolescence and cell death.[] GQ str...
The octapeptide angiotensin II (Ang II) is the major effector peptide of the renin-angiotensin system (RAS). It acts via two receptors, the AT and the AT receptor (ATR and ATR). The effects mediated by ATR are well known and include regulation of blood pressure and fluid/electrolyte balance.[] When ATR is expressed tog...
Physical appearance plays a central role in social interactions. “What is beautiful is good” wrote the Greek poet Sappho almost three millennia ago, and this affirmation still holds true in our society. Tangible proof of the prominent role of beauty in our society is the $220 billion (worldwide annual US dollars) in re...
Psoriasis (PsO) is an immune-mediated chronic disease that can affect both the skin and joints. It is characterized by well demarcated, erythematous plaques with an overlying silvery scale classically distributed on the extensor surfaces, scalp, and trunk, although it can affect any area of the skin (). Approximately 1...
Visual function is important for optimal orientation in functional and social life, and has an effect on physical and emotional well-being. Man is primarily visually motivated for survival, and sight is thought to account for about 80% of the function of all the five senses combined. Therefore, visual impairment leads ...
Psoriasis is a chronic inflammatory skin disease with a complex etiology involving genetic and environmental factors. The relationship between psoriasis and other diseases has drawn increasing interest in recent years. Growing evidence suggests that cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia,...
Pediatric primary care professionals and specialty providers sometimes find themselves unable to arrive at a clear diagnosis for patients with atypical symptom presentations. In such circumstances, providers may consider offering a diagnosis of Conversion Disorder (CD),– believing that, in the absence of a sound physic...
The use of polymeric nanomaterials such as dendrimers in the development and delivery of therapeutic compounds has emerged as a promising field of biomedical engineering. Dendrimers have a well-defined branching architecture consisting of an initiator core, a radiating interior structural layer composed of repeating ge...
In the last decade, many nanoparticle-based therapeutics have entered the pharmaceutical pipeline to improve the efficacy and reduce the systemic toxicity of a wide range of drugs. In fact, nanoparticle chemical and physical properties, such as shape, size, magnetic behavior, surface charge, and functionalization can b...
Due to their unique physicochemical properties, carbon nanotubes (CNTs) have applications in a wide variety of industries. One major area of application is in the manufacture of biomaterials and devices, which include biosensors and drug and vaccine delivery vehicles., CNTs have the advantage of superior mechanical str...
Pancreatic cancer is the fourth leading cause of cancer-related death in the US, with an overall 5-year survival rate of 5%. Even localized disease has a 5-year survival rate of only 18%–24%. According to the American Cancer Society’s estimates, 45,220 pancreatic cancers will be diagnosed in 2013 and 38,460 patients wi...
Nano technology has been widely used in biomedical research in recent years. Gold nanorods (AuNRs) are a nontoxic nonmaterial and are thought to be a promising tool for use in clinical diagnosis and treatment of diseases., AuNRs have a characteristic surface plasmon resonance,– with two distinctive absorption peaks: a ...
Although interprofessional care of patients is only now gaining momentum among Accountable Care Organizations and health systems, the Veteran’s Affairs (VA) Medical Center (VAMC) system has been incorporating this concept for decades. The goal of all outpatient VA Geriatric Evaluation and Management (GEM) programs is t...
Falls in older adults are a significant public health problem because the prevalence of falls is elevated among older adults and the consequences are severe. Approximately 95% of all hip fractures each year are attributed to falls, and 20%–30% of those who fall and suffer a hip fracture die within 1 year. The rapid gro...
Critical-size bone defects remain a major health care issue due to the difficulties in reconstructing large bone segments, and are caused by various diseases, such as trauma, abnormalities, congenital deficiency, or carcinological resection., The recent gold standard for treatment remains bone grafting with autologous ...
Dysregulation of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K-AKT-mTOR) pathway is frequently observed in tumors, including breast cancer. This pathway plays an important role in the regulation of cell proliferation, metabolism, motility, angiogenesis, and survival. Pathway hyp...
Panic disorder is characterized by the presence of recurrent panic attacks along with the following symptoms: persistent thoughts about the possibility of future attacks; worry about the implications and consequences of an attack; and changes in behavior because of previous attacks. Unexpected paroxysmal bursts of seve...
Glaucoma is a leading cause of blindness globally, and reducing intraocular pressure (IOP) is the key to glaucoma management according to several large-scale clinical trials. Among the known IOP-lowering treatments, trabeculectomy is regarded as the standard surgical modality in cases refractory to medical and/or laser...
xref #text A 15-year-old girl, accompanied by her parents, visited our outpatient clinic presenting with symptoms of suicidal behavior, irritability, and impulsivity. She was in her first year of high school and an only child. Her premorbid personality was calm and introspective. She underwent normal development, fulfi...
sup xref #text Great expectations are pinned on the ongoing interventional trials aimed to demonstrate that CTCs might be of value for guiding treatment of patients and predicting cancer progression. The results of the SWOG S0500 trial were recently presented at the 2013 San Antonio Breast Cancer Symposium. This random...
xref italic #text The methodology consisted of a retrospective case review of idiopathic AA cases seen in the Department of Hematology (by two of us: JWL, SAY), The Catholic University of Korea from 1981 to 2011. Idiopathic AA is a diagnosis by exclusion, after ruling out secondary bone marrow aplasia from various enti...
xref #text xref #text xref #text Systemic GPA often presents with symptoms of weight loss, fever, fatigue, arthralgia, and myalgia., GPA is characterized by granulomatous upper airways involvement in about 90% of patients. Upper respiratory tract symptoms include epistaxis, sinusitis, otitis media, deafness, hoarseness...
Major depressive disorder is a common condition usually associated with substantial symptom severity and role impairment. It is a significant public health concern across all regions of the world, with both prevalence and impairment severity slightly higher in high-income countries than in low-income to middle-income c...
Schizophrenia is a common mental disorder effected by the mutual influence of multiple genetic and environmental factors, and its heritability is up to 80%. In order to clarify the pathological mechanisms, many studies have been carried out over the years, but a consistent conclusion has still not been achieved. To dat...
Medication-related weight gain is common among patients with bipolar disorder (BD). This affects treatment satisfaction and may lead to reduced adherence. Patient-centered care, as defined by the Institute of Medicine (IOM), is “care that is respectful of and responsive to individual patient preferences, needs, and val...
In most cases, Alzheimer’s disease (AD) is preceded by a prodromal stage and amnestic mild cognitive impairment (aMCI) in which an individual’s memory is impaired to a greater degree than expected given the individual’s age, sex, and educational background, while the individual’s ability to perform the activities of da...
C a n c e r p a i n i s a s e r i o u s h e a l t h p r o b l e m , a n d i m p o s e s a g r e a t b u r d e n o n t h e l i v e s o f p a t i e n t s a n d t h e i r f a m i l i e s . P a i n c a n b e e n c o u n t e r e d i n e v e r y s t a g e o f c a n c e ...
Adipose triglyceride lipase (ATGL) has been identified as key enzyme of mammalian lipolysis, the hydrolytic cleavage of triglycerides into free fatty acids and diacylglycerols. ATGL is predominantly expressed in adipose tissue but found to a lesser extent in a variety of other tissues and organs, including kidney, ske...
Damage to peripheral nerves often results in abortive or inadequate regeneration due to inappropriate or missing connections between the injured nerve stumps. Various factors are required for successful regeneration in the peripheral nervous system, including the re-establishment of continuity of the peripheral nerve p...
Dysphagia is a common complication in stroke patients, with a reported incidence of approximately 55% during the acute phase of a stroke. Dealing with dysphagia is clinically important because it can affect the activities of daily living, quality of life, and prognosis of stroke patients. Using rehabilitation as treatm...
Metastatic castration-resistant prostate cancer (mCRPC) is uniformly fatal: in 2008, more than a quarter of a million deaths worldwide were attributed to this disease []. Nevertheless, progress has been made in extending the survival and improving the quality of life of men with mCRPC as improved therapies have become ...
xref #text A 28-year-old man experienced upper respiratory symptoms and presented with photophobia 5 days later. Examination on day 4 of photophobia onset revealed that he was afebrile and fully alert. He had no eye pain. His distance visual acuity, intraocular pressure, and funduscopic findings were normal. His near v...
Hemangioblastoma (HB) is a benign tumor (WHO grade 1) that comprises 2% of all intracranial tumors []. The risk of spontaneous hemorrhage was reported by Gläsker et al. [] as having a very low probability (0.0024% per patient per year), and the majority of hemorrhagic events are subarachnoid and intracerebral bleedings...
Metastatic breast cancer continues to be almost uniformly fatal; however, improvements in survival in developed countries have been documented []. This improvement can be attributed to better therapeutic and diagnostic tools for disease management. Yet, there is a limited array of tools for a noninvasive assessment of ...
Anthracyclines are active agents in the treatment of a wide variety of malignancies. For decades, the conventional anthracyclines have arguably been the most active agents against breast cancer in both the adjuvant and metastatic settings. However, the use of anthracyclines has been limited due to cumulative dose-relat...
xref #text A 35-year-old Japanese male presented to the Emergency Department of Okinawa Chubu Hospital with right hemiparesis. He had awakened from sleep with severe, sharp chest pain that was not accompanied by dyspnea. The chest pain subsided within 1 min without treatment, but medical evaluation was sought due to ob...
Membranous glomerulonephritis accounts for 20% of all cases of adult lupus nephritis []. Lupus membranous nephritis (MN) is relatively rare in children [, ]. Histologically, it is characterized by subepithelial immune deposits along the peripheral capillary loops leading to uniform thickening of the glomerular capillar...
Adenosquamous carcinoma (ASC) of the stomach is a rare malignancy, accounting for <1% of all gastric carcinomas [, , , ], and is characterized by a mixture of two components: adenocarcinoma and squamous cell carcinoma. In the adenocarcinoma component, the differentiated type is more frequently observed than the poorly ...
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Native kidney biopsy is a useful tool to establish a diagnosis, treatment and prognosis of glomerular and tubulointerstitial diseases. It reveals a diagnosis different than anticipated in 50% of cases, and its result modifies treatment in 20-50% of cases []. Yet, because of bleeding complications [,,], physicians are a...
xref #text The patient was a 55-year-old female who presented for evaluation of incoordination and gait disturbance. There were no issues during birth or early development. She was able to speak at 10 months and walked at 12 months. She had some learning disabilities, especially concerning visuospatial tasks, but was a...
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy that features a correspondingly poor prognosis. Its pathogenesis is poorly understood, especially at the molecular level, as the rarity of the disease renders comprehensive study difficult [, ]. As a result, therapeutic options are currently limited, with ...
Mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome, MPS VI, OMIM 253200) is an inherited metabolic disease caused by a deficient activity of -acetylgalactosamine-4-sulfatase (4-sulfatase, arylsulfatase B, ARSB, EC 3.1.6.12), a lysosomal enzyme involved in the degradation of dermatan sulfate (DS) [, ]. The clinical ...
Mock communities were prepared as previously described () by mixing seven representative oral bacteria ( 34, NCTC 10449, LR1, T14v, ATCC 10953, ATCC 33277, and PK 1910). Bacteria grown in liquid cultures were quantified using a Petroff-Hausser counting chamber, diluted in PBS and mixed in equal proportions to a f...
A cross-sectional, questionnaire-based survey was conducted among dentists working in Benghazi, Libya, between May and June 2012. Benghazi is the second largest city in Libya, with a population size of around 620,000 and a dentist-to-population ratio of six dentists for every 10,000 inhabitants (). The list of all dent...
Mice used in these studies were 2/3-month-old and 6-month-old littermates, maintained on a standard chow diet and kept with free access to food and water. All experiments were approved by the animal ethical committee of the University of Torino (Italy). Heme content in tissues and bile was quantified by the oxalic acid...
All experiments were performed according to UK Home Office regulations. Mouse models are described in . Immunoblotting and quantitative polymerase chain reaction were carried out by standard protocols (details in ; n = 3 independent experiments in triplicate). The human pancreaticobiliary tissue microarray was describe...
xref #text The evidence of a granular lymphocytosis greater than 2,000/μl lasting for more than 6 months has been generally accepted as the most relevant criteria for the diagnosis of disease [], considering that normally circulating LGL counts are 0.25 x 10/L []. This figure obviously requires additional evaluation of...
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic plasma cell disorder; it is a non malignant common condition affecting at least 3% of the population above the age of 50, with an average 1% annual risk of progression to Multiple Myeloma (MM) []. A monoclonal gammopathy can be associated with...
Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders which are morphologically characterized by bone marrow (BM) hypercellularity, uni- or multilineage dysplasia, and peripheral blood cytopenias. The incidence rate of MDS in the United States for the years 2003-2007 has been estimated at 4.3 per 100,...
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by impairment of cellular differentiation (also defined as ineffective hematopoiesis) progressive peripheral cytopenias and increased risk of developing acute myeloid leukemia (AML) []. Although the French-American-British (FAB) and Wor...
PNH is a rare and puzzling hematological disorder clinically characterized by the triad of bone marrow failure, severe thrombophilia and complement-mediated intravascular hemolysis []; the most evident sign of this latter manifestation (namely the hemoglobinuria resulting from intravascular hemolysis) accounts for the ...
xref italic #text the discovery of mutations in the Janus kinase 2 (JAK2) signalling pathway opened a new perspective in the pathophysiology and treatment of MF []. The frequency of JAK2V617F mutation ranges between 43-59% in MF. The most commonly detected mutation results in a guanine to thymine change at nucleotide 1...
In 1869, Nettleship and Tay described the first case of a “rare form of urticaria that result in a brownish discoloration” []. In 1878 Paul Ehrlich first described the mast cells “metachromasia”, along with the tendency for mast cells to be associated with blood vessels, glandular ducts, and nerves. Further in 1949, El...
Monoclonal B-cell lymphocytosis, or MBL for short, is an asymptomatic condition characterized by the presence of a circulating small clonal B-lymphocyte population in persons who do not have chronic lymphocytic leukemia (CLL), other B-cell lymphoproliferative disorder, or underlying conditions such as infectious or aut...
Psoriasis is a chronic, non-infectious inflammatory skin disease of genetic basis, characterized by excessive proliferation of the epidermis. It affects approximately 2–3 % of European population (Schafer, ). Numerous literature reports and clinical observations suggest that this condition has significant influence on ...
Demographic data shows that growing process of population ageing will cause increased participation of people aged over 45 in the labour force. Older adults are becoming increasingly important labour market reserves. It is important to maintain a good state of health and quality of life within that group and to counter...
Choroideremia (CHM) is an X-linked eye disorder affecting 1 in 50,000 men []. The condition is caused by a mutation in the gene that encodes Rab escort protein 1 (REP-1) []. Males with CHM suffer from progressive vision loss beginning with night blindness at a young age, leading to complete blindness later in life. Fe...
Retinoblastoma (RB; OMIM ) is the most frequent primary intraocular malignant tumor in children, probably arising from cone precursor cells []. RB mainly affects children under 6 years old, with an incidence rate of 1 case per 15,000 to 20,000 live births [,]. According to the “two-hit” hypothesis, RB includes heredita...
The RPE is a monolayer of nondividing cuboidal cells that are critically important for the nourishment and overall integrity of photoreceptor cells []. Thus, RPE cells are a primary target of studies that aim to understand the fundamental mechanisms of cell survival. Failure in sustaining RPE cell viability is a key ev...
Hereditary retinal dystrophies (RDs) are a large group of clinically and genetically heterogeneous retinal diseases that constitute a major cause of vision handicap in the global population []. They are typically characterized by the progressive loss of rod and cone photoreceptor cells often leading to severe blindness...
The limbus is anatomically located between the cornea and the conjunctiva on the ocular surface. The basal layer of the limbal epithelium is enriched with a special cell population, named limbal epithelial stem cells (LSCs) []. The cornea contains a stratified squamous epithelium that turn overs rapidly. Renewal of the...
Glaucoma is the third most frequent cause of blindness worldwide [], and is known to affect both humans and numerous dog breeds. Several types of glaucoma exist, including primary angle-closure glaucoma (PACG), which is three times more prevalent in humans of Asian descent than in European populations [-]. In human pat...
Vitelliform macular dystrophy (VMD; ), also called Best disease [], is a clinically heterogeneous and pleomorphic disease, in most cases showing an autosomal dominant pattern of inheritance with extremely variable penetrance and expressivity. (chromosome 11q12-q13) [], the only gene virtually involved in all dominant ...
Hepcidin is a small polypeptide hormone, consisting of 25 amino acids, that is obligatory for iron regulation [,]. Hepcidin is expressed predominantly in the liver. The peptide exhibits bactericidal activity at high non-physiologic concentrations; this coupled with the peptide’s hepatic origin was the basis of the name...
xref #text A relatively brief course of antenatal GCs administration (dexamethasone or betamethasone) improves survival and appears to protect against brain damage,,,,. In clinical trials and observational studies, antenatal administration of GCs has been associated with a decreased risk of intraventricular hemorrhage ...
xref #text Since Broxmeyer had suggested that CB could be a source of transplantable hematopoietic stem cells (HSCs), a lot of experimental studies have been performed for clinical applications. The scientific findings revealed that HSCs in CB have an extensive proliferative capacity, which exceeds that of bone marrow ...
It is estimated that more than 1,800 babies worldwide contract human immunodeficiency virus (HIV) from their mothers every day. Many of these cases occur in Africa,. The probability of infection from mothers who do not receive treatment is higher in Africa (25%-52%) than the United States (US) or Europe (12%-30%). HIV ...
Fanconi anemia (FA) is a rare autosomal and X-linked recessive disorder, characterized by physical abnormalities, progressive bone marrow failure (BMF), hypersensitivity to DNA cross-linking agents and predisposition to malignancy. It was first described in 1927 by Fanconi, who described a family in which three childre...
End-stage renal disease (ESRD), the terminal stage of chronic kidney disease (CKD), is a growing health problem worldwide. According to the United States Renal Data System (USRDS), the annual incidence of ESRD increased from 13 per million of the age-related population (MARP) in the 1988 to 15 per MARP in the 2003. Eur...
Lowe syndrome (OculoCerebroRenal syndrome of Lowe) is an X-linked, recessive disorder characterized by congenital cataracts, mental retardation, and proximal renal tubular dysfunction (Fanconi syndrome). It is a rare disease with an estimated prevalence of 1-2 in 1,000,000 patients. The clinical manifestations vary amo...
xref italic #text xref italic #text Typical clinical features of MDC1A or merosin deficient congenital muscular dystrophy include severe floppiness at birth, elevated serum CK, delayed motor milestones, white matter changes as seen on brain MRI, and normal intelligence. However, merosin-positive CMD generally presents ...
Toxic epidermal necrolysis (TEN) is a life-threatening cutaneous reaction associated with 30% mortality. Inappropriate immune activation is triggered in response to certain drugs or their metabolites. Numerous medications have been implicated as causes of TEN, the most frequently associated drugs include aromatic antic...
Heart transplantation remains the treatment of choice for patients with end-stage heart failure refractory to medical or surgical management []. Early graft dysfunction often occurs after implantation for various reasons including ischemia-reperfusion injury and failure of donor heart preservation [,]. Mechanical circu...
Coronary artery revascularization for multivessel disease can be managed through various modalities, and the patency of left internal thoracic artery (LITA)-to-left anterior descending artery (LAD) anastomosis is the best among the options. Recent reports have noted a 10-year patency rate of 95% to 98% [,]. The patency...
In 1961, Jarvi and Saxen [] first described an uncommon, non-encapsulated, benign tumor in the subscapular region characterized by the proliferation of elastin fibers in a stroma of collagen and fatty connective tissue. Elastofibroma dorsi (ED) is a relatively rare soft-tissue pseudo-tumor localized in the infra- or pe...
Implanted venous access devices or permanent central venous access systems (PCVASs) have been routinely used in oncologic patients since the 1980s []. They are made of a central venous catheter connected to a chamber or reservoir surgically implanted in a subcutaneous pocket []. The most common insertion sites are the ...
xref #text Sixty-seven patients underwent pleural biopsies over an 18-month period. The criterion for patient inclusion was that their pleural effusion remained undiagnosed after thoracentesis. Patients were randomized into two groups. Group A contained 36 patients with hydrothorax who underwent closed pleural biopsies...
Two patients were referred for an operation. They were diagnosed with an interrupted aortic arch (IAA) with ventricular septal defect (VSD) by echocardiography. Computed tomography (CT) was reviewed for further evaluation and operational planning. Prostaglandin therapy was applied, but mechanical ventilation was not re...
sup #text Cold agglutinin disease (cold antibody disease) is caused by autoantibodies that react at decreased blood temperature and produce agglutination or hemolysis of red blood cells [,,]. The causes of this situation include infections (especially mycoplasmal pneumonias or infectious mononucleosis), lymphoprolifera...
A 50-year-old female presented to Pusan National University Hospital with a 1-month history of fatigue, loss of weight, and shortness of breath. She had poor oral hygiene and a low socioeconomic status. Her medical history was unremarkable. On examination, she presented with fever and sweating, along with marked conjun...
The patient was a 55-year-old woman with a four-year history of chest pain at rest. The symptom was aggravated at night when she was lying down. She visited a cardiologist and was examined by treadmill testing, but no abnormal findings were noted. The patient subsequently developed orthopnea, for which she was medicall...
xref #text Trichinellosis, also known as trichinosis, is a food-borne parasitic infection widely dispersed in various regions all over the world. Further, the disease is endemic in many areas of Asia, Eastern Europe, and Latin America. Humans are exposed to the infection by ingestion of undercooked or raw meat of anima...
A 74-year-old man presented with mild dyspnea and chest discomfort for 30 months. The symptoms had deteriorated 3 months before his visit to our hospital. Trans-thoracic echocardiographic findings showed a left atrial echogenic mass (2×1.5 cm) (). A provisional diagnosis of a left atrial (LA) myxoma was made, and the p...
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A 62-year-old male with a history of tobacco abuse and newly diagnosed small-cell lung cancer (T1N1M0) two months earlier was readmitted in the hospital with shortness of breath for one day. He had been on chemo-radiation for his lung cancer over the course of the previous month. Meanwhile, four days prior to this admi...
A 45-year-old male patient was admitted to an outpatient clinic with blunt thoracic trauma after falling from height (work-related accident) and was referred to Kocaeli University Faculty of Medicine after the detection of ischemia on his electrocardiogram. In the physical examination, the vital signs were stable, but ...
xref sub #text Despite advances in surgical techniques, the mortality rates of ATAAD have remained high in patients with brain malperfusion. Occlusion of the aortic arch vessels, which is propagated from the dissected aorta, commonly leads to neurological deficit []. The main factor causing malperfusion is the dynamic ...
A 73-year-old man visited Konkuk University Medical Center with a complaint of severe abdominal pain. He had been diagnosed with chronic renal failure and treated with hemodialysis for seven years. The patient had undergone endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) (size: 82 mm) utilizing ...
A 48-year-old female patient visited our cardiovascular outpatient department for treatment of a mass-like dilated neck vein as a procedure concomitant with thyroid cancer surgery. We could detect the gross engorgement of the neck mass in the supine position or by using the Valsalva maneuver when the patient was in an ...